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Literatures show that fluoride affects diverse signaling
2020-08-04
Literatures show that fluoride affects diverse signaling pathways associated with proliferation and apoptosis, such as mitogen-activated protein kinase (MAPK), p53, activator protein-1 (AP-1) and nuclear factor kappa B (NF-κB) pathways (Iwatsuki and Matsuoka, 2016; Zhang et al., 2007, 2008). It is a
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Both meiotic COs and NCOs require
2020-08-04
Both meiotic COs and NCOs require DNA synthesis, current data from sequencing also suggest that COs require more DNA synthesis than NCO 63., 64., 65.. However, analysis of the role of DNA synthesis in NCOs remains relatively uncharacterized. Emerging evidence points to a role for either Polδ or Polε
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br Materials and methods br Results br Discussion
2020-08-04
Materials and methods Results Discussion A significant decrease in fluorescence was observed after the treatment of pure DNA with alkylating compounds. This decrease was characterized by a dose-response relationship. Mass spectrometry and additional fluorescence measurements ruled out the c
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ALDH A isoform expression has
2020-08-04
ALDH1A1 isoform expression has also been detected in gliomas, being correlated with histological grade, proliferation, colony formation, and invasiveness [5]. ALDH1A1 expression was elevated in CSCs of human GBM cell lines, coexpressed with other CSC markers Musashi-1 and Sox-2, and it was proportio
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The initial SAR conducted indicated
2020-08-03
The initial SAR conducted indicated that a pyridine ring was broadly tolerated in domain C so we assessed the impact of introducing a pyridine in domain B (). Exchanging the pyridine ring between domains ( vs. ) led to a balanced profile at both receptors. Maintaining phenyl rings in both domains (
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This study focuses on mechanisms of reciprocity between DGTS
2020-08-03
This study focuses on mechanisms of reciprocity between DGTS and PC in fungi during Pi starvation. We report changes in expression of the BTA1 gene and two PC biosynthesis genes during phosphate starvation of F. velutipes culture. We describe the deduced amino Alamethicin synthesis sequence and geno
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br Thermodynamic modeling br Selection of data The solutes w
2020-08-03
Thermodynamic modeling Selection of data The solutes were selected based on the set of data needed to evaluate the CPA-EoS for prediction of their solubility in CO2 + cosolvent, as shown in Fig. 1. Critical temperatures, melting temperatures and enthalpies of fusion of the solutes are required
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The afore described studies enabled the identification of
2020-08-03
The afore-described studies enabled the identification of conditions suitable for MS-based analysis of potential vCPH inhibitors, i.e. vCPH (1 µM), (NH₄)₂Fe(SO₄)₂ (50 µM), sodium l-ascorbate (100 µM), 2OG (disodium salt, 30 µM), PA-Hyp-KPAPK (10 µM), HEPES pH 7.5 (50 mM). Since the active sites of t
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Routine administration of exogenous GC is
2020-08-03
Routine administration of exogenous GC is pertinent during late gestation, particularly in women who are at risk of delivering a preterm infant, aiming at ensuring proper neonatal outcome and survival (Kamath-Rayne et al., 2012). Unfortunately, despite its beneficial roles in foetal survival, variou
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For C NNC Abi Dargham et
2020-08-03
For [11C]NNC 112, Abi-Dargham et al. performed a test-retest study using arterial input function and kinetic modelling using the 2-tissue compartment model (2TCM) [30], evaluating a range of different outcomes measures. The test-retest variability for most parameters were similar for striatal and co
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In a fashion similar to prostate and bladder cancers EDNRB
2020-08-03
In a fashion similar to prostate [45] and Vanoxerine cancers [51], EDNRB promoter methylation was frequently observed in RCC lines and human renal tumors. Hypermethylation of the 5′ CpG island in the regulatory region of EDNRB likely results in inhibition of ETB expression and perhaps in the clonal
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We next focused our design building into the
2020-08-03
We next focused our design building into the ribose binding site, which had not been yet utilized in this effort. Compounds bearing a series of five-membered aromatic heterocycles (compound , ) showed reduced inhibition of the Gram-positive isozymes compared with compound , but a 20-fold improved po
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Additionally of outmost important is the location of
2020-07-31
Additionally, of outmost important is the location of the different CpG islands in relation to the transcription starting site (TSS) of the promoter as well as their interaction with transcription activators or repressors. It has been shown that methylation at the downstream region of the TSS in the
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br Histology Morphologically Ewing sarcoma is
2020-07-31
Histology Morphologically, Ewing sarcoma is composed of sheets of small round cells with a high nuclear to cytoplasmic ratio and is often classified by pathologists into a group of small round blue cell tumors that include neuroblastoma, alveolar rhabdomyosarcoma and lymphoblastic lymphoma. The c
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Nitric oxide NO is a well
2020-07-31
Nitric oxide (NO) is a well-characterized signaling molecule that mediates various physiological effects [11]. In addition to its physiological significance, NO influences the functional states of transcription factors and other signaling molecules and modulates gene expression. Multiple studies hav
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