• br Conclusions This study showed that in

  2021-01-08

  

  Conclusions This study showed that in EOC cells, tyrosine kinase receptor DDR1 was expressed mainly in EOC CFM 4 with an Epithelial phenotype. The repressed expression of DDR1 in EOC cells with Mesenchymal phenotype could be due to the higher CpG methylation levels observed at the promoter of th

• In summary in the present

  2021-01-08

  

  In summary, in the present study we found that CysLT1 receptor attenuates while CysLT2 receptor facilitates OGD-induced PC12 cell death as confirmed by receptor over-expression and antagonism. However, we cannot explain why their roles are distinct and why the cell size is increased in the CysLT2 re

• The changes in the chemokine

  2021-01-08

  

  The changes in the chemokine receptors CCR-5 and CXCR-4 in women and men with PTSD are completely different. In the group of women with PTSD alone the level of this hiv protease increased six times, whereas, in women with APD and PTSD, the level of the receptor CCR-5 was eight times higher than in

• br The orphan estrogen related receptor exists as three

  2021-01-08

  

  The orphan estrogen-related receptor exists as three subtypes (ERRα, ERRβ, and ERRγ) in the human genome. ERRα is expressed in metabolically active tissues such as muscle and adipose. ERRγ is expressed in the spinal cord and CNS. ERRβ appears to play a role in development, as postnatal expression

• Our present results support a major

  2021-01-08

  

  Our present results support a major role of EP1 receptors in peripheral heat sensitization and a smaller contribution to central heat sensitization but no contribution to mechanical sensitization. While the contribution of peripheral EP1 receptors to heat hyperalgesia is in good agreement with the a

• Moreover considering that several polyphenols and flavonoids

  2021-01-08

  

  Moreover, considering that DCC-2036 several polyphenols and flavonoids (i.e. chalcones, flavanones, resveratrol derivatives, ellagic acid) are reported to inhibit tyrosinase and elastase (Pillaiyar et al., 2017; Xing et al., 2016; Wittenauer et al., 2015), the relations between enzyme inhibitory ac

• The potential existence of ER stress was

  2021-01-08

  

  The potential existence of ER stress was first examined in EVTs in placental bed biopsy specimens obtained from pregnancies complicated by early-onset preeclampsia. It was then tested whether ER stress can modulate MMP-2 activity before elucidating the role of proinflammatory cytokines in the induct

• br Materials and methods br Results

  2021-01-08

  

  Materials and methods Results In the leaves of the studied varieties, one to three nucleoli per nucleus were observed (Fig. 1a), except for the variety Bastardo were a maximum of two nucleoli per nucleus were detected. In the root-tip cells, most of the varieties presented one to three nucleo

• Common to all models for nuclear transport is the binding

  2021-01-08

  

  Common to all models for nuclear transport is the binding of importins/exportins to FG repeats found in about a third of the ∼30 nucleoporins, the so-called FG-Nups (Iovine et al., 1995, Rexach and Blobel, 1995); for review, see Grossman et al. (2012), Stewart (2007), and Terry and Wente (2009). FG-

• Models and theories The CPA equation of

  2021-01-07

  

  Models and theories The CPA equation of state is composed predominantly of two parts: physical item and the association item based on the thermodynamic perturbation theory [21], [22], [26], [27]. The physical item is used to represent intermolecular physical interaction, usually representing the SR

• There have been attempts to stimulate the dopaminergic syste

  2021-01-07

  

  There have been attempts to stimulate the dopaminergic system to influence cognition in women around menopause who have subjective complaints about their cognition by Epperson et al. (Epperson et al., 2011, Epperson et al., 2015). In perimenopausal and postmenopausal women, Epperson et al. found tha

• Other studies have investigated the role of HDAC inhibitors

  2021-01-07

  

  Other studies have investigated the role of HDAC inhibitors in particular signaling pathways mediated by EWS–FLI1 (Matsumoto et al., 2001). A recent investigation, showed a physical association of EWS–FLI1 and HDAC1 that helps mediate a disruption in the p53 activation of downstream targets (Li et a

• W-7 hydrochloride sale Our previous high throughput screenin

  2021-01-07

  

  Our previous high-throughput screening (HTS) campaign using automated, robust, and sensitive fluorescence based W-7 hydrochloride sale assay [10], [11] led to the identification of several EPAC specific inhibitors (ESIs), and was subsequently followed by extensive hit-to-lead optimizations [20], [2

• 46619 br Lymphoplasmacytic lymphoma Waldenstrom macroglobuli

  2021-01-07

  

  Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia Lymphoplasmacytic lymphoma (LPL) and its subgroup Waldenstrom macroglobulinemia (WM) are rare and indolent lymphomas that arise from fully differentiated B cells. The only family of GPCRs that has been well studied in LPL/WM is the chemokin

• br Acknowledgments We thank our colleagues who have contribu

  2021-01-07

  

  Acknowledgments We thank our colleagues who have contributed to our understanding of the gli protein and the structure and function of APC/C, and apologize to those whose work we were unable to cite here. We thank J. Rajan Prabu for making the movies showing APC/C conformational changes. Our wor

15366 records 679/1025 page Previous Next First page 上5页 676677678679680 下5页 Last page