• Receptor guanylyl cyclases play essential roles

  2022-02-22

  

  Receptor guanylyl cyclases play essential roles in cardiovascular and gastrointestinal (patho-)physiology, reproduction biology, cell proliferation, bone growth and sensory signal transduction and, therefore, are important pharmacological targets. Accordingly, the receptor guanylyl cyclase agonists

• The CNP pGC B cGMP pathway

  2022-02-22

  

  The CNP/pGC-B/cGMP pathway has been reported to be potent inhibitor of fibrosis, from an intrinsic compensatory protective response as well as a therapeutic in cardiorenal injury and disease states [6,12,13,22,30]. Indeed, fibrosis is a progressive process leading to increased risk for morbidity and

• Reduction of the hydrolysis of ATP is an important strategy

  2022-02-22

  

  Reduction of the hydrolysis of ATP is an important strategy to reduce ischemia/reperfusion injury. Increased intracellular concentrations of solutes secondary to ATP depletion are known to result in osmotic swelling that may be sufficient to cause sarcolemmal rupture. Cinaciguat activates sGC direct

• Urinary hydroxypyrene OHP is a widely used biological

  2022-02-22

  

  Urinary 1-hydroxypyrene (1-OHP) is a widely used biological marker of exposure to PAHs and indicator for internal dose of activated PAHs (Jongeneelen, 1987, Adonis et al., 2003). PAH metabolites may be excreted either as free or as conjugated compounds. When 1-OHP is measured after treating the urin

• br Material and methods br

  2022-02-22

  

  Material and methods Results and discussion Unlike many fruits such as bananas and tomatoes, known as climacteric fruits, in which ripening is regulated by a burst of isoniazide biosynthesis and an increase in respiration, pepper fruits, which do not follow this pattern, are called non-climac

• While a role for YAP TAZ signaling in

  2022-02-22

  

  While a role for YAP/TAZ signaling in oligodendrocytes has not been described, these AZD1390 sale are also responsive to mechanical stimuli. OPC proliferation and migration can be altered by plating on substrates of varying stiffness [20], resulting in differentiation in a density-dependent manner.

• Introduction Molecular imprinting technology is a method tha

  2022-02-22

  

  Introduction Molecular imprinting technology is a method that combines the material chemistry, biochemistry, and polymer chemistry and has the ability to specifically identify target analytes on shape, size and functional groups. Molecular imprinting polymer (MIP) is developed based on molecular im

• br The methyl aspartate receptor NMDAr hypofunction hypothes

  2022-02-22

  

  The -methyl--aspartate receptor (NMDAr) hypofunction hypothesis of schizophrenia correlates disease symptomology with glutamatergic neurotransmission dysfunction., , , Therefore, inhibition of glycine transporter 1 (GlyT1) to elevate synaptic levels of glycine and potentiate NMDAr signaling is a

• This data is in accordance

  2022-02-22

  

  This data is in accordance with our recent results on the influence of cholesterol-depleting agent methyl-β-cyclodextrin on platelets (Borisova et al., 2011a). Dissipation of the proton electrochemical gradient of secretory granules by methyl-β-cyclodextrin did not evoke the release of endogenous gl

• GK also called hexokinase IV or

  2022-02-22

  

  GK, also called hexokinase IV or D, is a glycolytic enzyme that converts H-Lys(Z)-OH to glucose-6-phosphate. GK has unique characteristics compared with those of the ubiquitously expressed hexokinase isoforms I–III, and is predominantly expressed in the pancreas and liver. In pancreatic β-cells, GK

• AKR D is very highly expressed in human

  2022-02-22

  

  AKR1D1 is very highly expressed in human liver and based upon the observations outlined above, with respect to other steroid hormone pre-receptor metabolising enzymes, it is entirely plausible that AKR1D1 could represent a critical regulatory step in the control of metabolic phenotype within the liv

• We detected the FFAR protein with

  2022-02-21

  

  We detected the FFAR2 protein with a molecular mass of about 50 kDa, which is comparable to the main band detected in pigs (Li et al., 2014) but different from the calculated size based on the sequence (Wang et al., 2009). The size difference can be explained, at least in part, by glycosylation site

• In principle an ideal Fenton reaction element should have

  2022-02-21

  

  In principle, an ideal Fenton reaction element should have multiple oxidation states to form a redox cycle in the process of H2O2 decomposition to HO•. Although iron is very effective in catalyzing Fenton reaction, it requires a low pH value (pH 2-4) to reach the optimal catalytic efficiency, which

• In addition to Rabs several proteins

  2022-02-21

  

  In addition to Rabs, several proteins have been shown to interact with Rabphilin3a, for instance the GluN2A subunit of the NMDA receptor, PSD-95 ([56,57] and references therein), Rabaptin-5, α-actinin [16] and SNAP-25 [21,23,41,61]. Only the latter has been reported to participate in the AR. Explori

• In this study there is a

  2022-02-21

  

  In this study, there is a limitation in the study of sex differences. Only female rats were used in our study. This is because the rats cannot urinate autonomously after SCI. Manual dub inhibitor emptying was needed until reflex bladder emptying was established (Lu et al., 2008, Ma et al., 2015). B

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