• Diffusion tensor imaging DTI is particularly powerful for ev

  2018-11-05

  

  Diffusion tensor imaging (DTI) is particularly powerful for evaluating microstructural integrity of white matter by analyzing the restricted diffusion of water molecules (Catani, 2006). It can detect early neuropathological changes using quantitative indicators such as FA, which is thought to reflec

• br Introduction Type diabetes mellitus

  2018-11-05

  

  Introduction Type 2 diabetes mellitus (T2DM) and Alzheimer\'s disease (AD) are the most common age-associated disorders and the prevalence of the diseases is increasing with population aging (Biessels et al., 2008; Exalto et al., 2012; Stumvoll et al., 2005; Umegaki, 2014). The epidemiological st

• To investigate how UL expression

  2018-11-05

  

  To investigate how UL49.5 expression promoted OV anti-tumor activity, we first determined if UL49.5 expression enabled viral persistence in tumors. After establishing bilateral s.c. MBT2 tumors, left flank tumors were treated with BV49.5 or the FS variant as in Fig. 3a. Two days after the final inje

• These promising laboratory findings and preclinical results

  2018-11-05

  

  These promising laboratory findings and preclinical results inspired the current prospective, randomized, phase I/II clinical trial (, AdiFLAP Trial) designed to evaluate the safety and efficacy of AGTP in patients with chronic myocardial infarction undergoing CABG. Patients were enrolled if they we

• Finally we sequenced the DNA extracted from the white blood

  2018-11-05

  

  Finally, we sequenced the DNA extracted from the white-blood hiv protease inhibitor (WBC) of 39 cfDNA TP53-positive patients, from which material was available (19 cases and 20 controls). Five cfDNA TP53 mutations (from one case and four controls) were detected in the WBC DNA, with similar AFs to t

• dextromethorphan hydrobromide Small cell lung cancer SCLC ac

  2018-11-05

  

  Small-cell lung cancer (SCLC) accounts for about 15% of all lung tumors and has a 5-year survival below 5%. While SCLC tumors are initially sensitive to chemotherapy, they invariably relapse with a resistant and deadly disease. We and others have found that, contrary to lung adenocarcinomas and squa

• Among the participants in our

  2018-11-05

  

  Among the 1303 participants in our study, 74% (n=964) reported xerostomia (Table 2). Xerostomia prevalence was highest among SS participants (87.4%, 95% CI: 84.8%–89.8%) followed by Sicca participants (72.4%, 95% CI: 67.4%–77.0%) and the ISS group (38.1%, 95% CI: 32.0%–44.4%). The absolute differenc

• Autophagy also plays a role in

  2018-11-05

  

  Autophagy also plays a role in response to treatment. An extensive literature suggests that autophagy can protect cancer cells against commonly used cancer therapies including a wide array of different drugs and radiation (Thorburn et al., 2014; Rebecca and Amaravadi, 2015). Such studies are the bas

• Alzheimer s disease is the most common progressive

  2018-11-05

  

  Alzheimer\'s disease is the most common progressive neurodegenerative dementia and is characterized by the accumulation of plaques and intra-neuronal fibrillary tangles, where the former consists of beta-amyloid peptides (Aβ) that are highly insoluble and toxic (Querfurth and LaFerla, 2010), and the

• Primary orebodies occur at to m depth

  2018-11-05

  

  Primary orebodies occur at 150- to >450-m depth, having irregular to elongate lens and vein shapes. Grade control data and exploration drilling define significant concentrations of primary uranium ore around the granite porphyry dikes (Fig. 4; Jiangxi No.264 Geologic Party, 1987). Where they are awa

• Since the creation of in it

  2018-11-05

  

  Since the creation of , in 2008, it has never been a year as exciting as 2014. Over the past year, we accomplished two of the main goals of the editorial board: indexation in an international database (Scopus), including the indexation of our entire previous archive, and the management by a major sc

• br Methods The experimental study was performed in

  2018-11-05

  

  Methods The experimental study was performed in accordance with the ethical standards laid down in the Declaration of Helsinki. Its protocol was approved by the Ethics Committee of the Siberian Branch of the Russian Academy of Medical Sciences (#2/07.06.2009). Informed written consent was obtaine

• Notably the sleeping environment in which home studies are c

  2018-11-05

  

  Notably, the sleeping environment in which home studies are conducted is often not standardized especially with respect to ambient temperatures due to seasonal changes. According to the data collected from Summer 2012 to Summer 2014 in Australian houses by the Faculty of Architecture, The University

• During the fabrication process variations of global diameter

  2018-11-05

  

  During the fabrication process, 1% variations of global diameters in the fiber may occur where 2% is tolerable [37]. It is clearly reported in Table 1 that there are no much changes of investigated guiding properties value for ±1% variations of global parameters. So after fabrication process, there

• PD 0332991 cost Radiation therapy RT induces tumor cell deat

  2018-11-03

  

  Radiation therapy (RT) induces tumor cell death by eliciting irreparable DNA damage and cell cycle arrest, thus providing a robust source of antigens. By upregulating MHC class I expression, RT enhances antigen presentation and T cell recognition of irradiated tumor cells, sensitizing them to cytoto

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