SATB acts as a master regulator

2018-10-20

SATB2 acts as a master regulator by binding to genes which regulate embryonic development, cell differentiation, pluripotency, and cell survival (Ordonez, 2014; Rosenfeld et al., 2009; Zhao et al., 2014). We have discovered the SATB2 direct thrombin inhibitor in the promoters of c-Myc, Nanog, Kl4,

In this regard induced pluripotent stem cells iPSCs converge

2018-10-20

In this regard, induced pluripotent stem orexins (iPSCs) converge to a better-defined ground state of pluripotency (Hackett et al., 2013). They can be differentiated into all cell types of the organism and—while in pluripotent state—cultured virtually indefinitely without signs of replicative senes

Expression of Sox alone was sufficient to induce neurogenesi

2018-10-20

Expression of Sox2 alone was sufficient to induce neurogenesis without requirement for coexpression of a proneural transcription factor. This is surprising, as Sox2 function in neural stem cells is to promote self-renewal rather than neuronal differentiation (Graham et al., 2003; Pevny and Nicolis,

To trace host to graft connectivity of transplanted hESC der

2018-10-20

To trace host-to-graft connectivity of transplanted hESC-derived neurons, we next generated hESC lines that stably expressed the tracing and control constructs (Figures 2A and S2A). The engineered hESCs were differentiated using a protocol that results in a high yield of authentic and functional ven

Introduction Oligodendrocyte progenitor cells OPCs in the

2018-10-20

Introduction Oligodendrocyte progenitor CB-5083 (OPCs) in the mammalian cerebral cortex have been suggested to originate from the ventral telencephalon (He et al., 2001; Marshall and Goldman, 2002). However, cell fate mapping using Emx1::Cre transgenic mice show that many oligodendrocytes in the co

Phenyl sulfate Raman microspectroscopy is a marker free

2018-10-20

Raman microspectroscopy is a marker-free method that can be used to characterize single cells based on a pattern of molecular vibrational modes, which reflects the composition of intracellular proteins, lipids, nucleic acids, and Phenyl sulfate (Puppels et al., 1990). Notingher et al. (2004) invest

br Results br Discussion We have conducted experiments to

2018-10-20

Results Discussion We have conducted experiments to clarify whether Pten regulates HSCs cell autonomously or non-cell autonomously. Our data confirm that Pten regulates HSCs via both cell-autonomous and non-cell-autonomous mechanisms (Figure 1). The data also show that the cell-autonomous effe

Hello world!

2018-07-29