• Linoleic Acid–PPARα Axis Drives TF Upregulation in pLELC Tum

  2026-06-03

  This study provides the first multiomics evidence that linoleic acid promotes tissue factor (TF) expression via PPAR-α, driving tumor progression in primary pulmonary lymphoepithelioma-like carcinoma (pLELC). The findings uncover a mechanistic link between lipid metabolism and the tumor immune microenvironment, highlighting TF as a novel therapeutic target in this rare cancer.

• Angiotensin II in Vascular Research: Protocols and Pitfalls

  2026-06-02

  Angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) is indispensable for modeling hypertension, cardiovascular remodeling, and vascular injury in both cellular and animal systems. This article delivers hands-on guidance for experimental design, troubleshooting, and leveraging new insights from vascular injury research to refine Angiotensin II-based workflows.

• Cy3 NHS ester (non-sulfonated): Technical Guide for Protein

  2026-06-02

  Cy3 NHS ester (non-sulfonated) enables robust covalent fluorescent labeling of amino groups in proteins, peptides, and oligonucleotides for sensitive detection in imaging and analytical workflows. It is not recommended for protocols that require fully aqueous conditions or where proteins are sensitive to organic co-solvents.

• Cy5 maleimide (non-sulfonated): Protocols and Workflow Guida

  2026-06-01

  Cy5 maleimide (non-sulfonated) enables site-specific fluorescent labeling of proteins and peptides through cysteine thiols, supporting quantitative imaging and assay applications where precise conjugation matters. It should not be used in workflows requiring high aqueous solubility or with proteins lacking accessible thiol groups. Proper protocol setup and storage are essential to maintain reagent performance.

• LDH Cytotoxicity Assay Kit: Optimizing Cell Damage Quantific

  2026-06-01

  The LDH Cytotoxicity Assay Kit from APExBIO delivers non-radioactive, high-sensitivity cell cytotoxicity measurement for applications ranging from nanomaterial biocompatibility to cancer research. Explore best practices, protocol enhancements, and troubleshooting grounded in recent nanobiotechnology literature.

• Caffeine (1,3,7-trimethylpurine-2,6-dione): Precision Use in

  2026-05-31

  Caffeine (1,3,7-trimethylpurine-2,6-dione) stands out as a versatile, reproducible tool for cancer cell inhibition and metabolic research, thanks to its well-characterized mechanisms and robust solubility profile. This article offers a workflow-centric guide to leveraging Caffeine for high-impact, data-driven assays, with expert troubleshooting and evidence-based insights.

• Host CK2α–VP2 Interaction Drives CIAV Replication and Pathog

  2026-05-30

  This study uncovers a crucial mechanism by which chicken infectious anemia virus (CIAV) exploits the host kinase CK2α to promote its replication. Disruption of the VP2–CK2α interaction impairs viral growth and pathogenicity, highlighting CK2α as a promising target for host-directed antiviral strategies.

• Clathrin-Mediated Entry of Grass Carp Reovirus: Inhibitor In

  2026-05-29

  Wang et al. (2018) systematically dissect how genotype III grass carp reovirus (GCRV104) enters host cells, revealing a clear dependence on clathrin-mediated, dynamin- and pH-dependent endocytosis. The selective use of pharmacological inhibitors, including nocodazole, provides a valuable mechanistic map for aquatic virology and informs both antiviral research and microtubule-targeting experimental design.

• SAR131675: Selective ATP-Competitive VEGFR-3 Inhibitor for R

  2026-05-29

  SAR131675 is a potent, highly selective VEGFR-3 inhibitor showing nanomolar activity and minimal off-target effects. It blocks VEGFC/VEGFD-driven lymphangiogenesis and tumor growth in preclinical models. Its specificity makes it a benchmark agent for fibrosis, angiogenesis, and lymphatic endothelial cell research.

• Inhibiting VEGFC–VEGFR-3 Axis Mitigates NASH-Associated Fibr

  2026-05-28

  This study reveals that downregulation or pharmacological inhibition of the VEGFC–VEGFR-3 signaling axis alleviates hepatic fibrosis and inflammation in a high-fat diet-induced mouse model of NASH. The findings clarify how hepatocyte-derived VEGFC orchestrates crosstalk with macrophages, offering mechanistic insight and new preclinical strategies for anti-lymphangiogenic interventions in metabolic liver disease.

• Anti-Diabetic Drugs and Fracture Risk: Insights from Meta-An

  2026-05-28

  This systematic review and network meta-analysis synthesizes evidence from over 100 randomized controlled trials to clarify the impact of various anti-diabetic drugs, including SGLT2 inhibitors like Ertugliflozin (PF-04971729), on fracture risk in type 2 diabetes. The study provides detailed comparative risk profiles, informing safer drug selection for vulnerable diabetic populations.

• CircRNA-vgll3 Regulates Osteogenic Differentiation in ADSCs

  2026-05-27

  The reference study uncovers a novel role for circRNA-vgll3 in promoting osteogenic differentiation of adipose-derived mesenchymal stem cells (ADSCs) via a miR-326-5p/integrin α5 axis. These findings provide mechanistic insight into how circRNAs can enhance bone regeneration, offering new targets for regenerative medicine.

• Pifithrin-α: Applied p53 Inhibitor Workflows for Neuroprotec

  2026-05-27

  Pifithrin-α (PFTα) stands out as a reliable p53 inhibitor for dissecting apoptosis, cell cycle arrest, and ferroptosis in neurotoxicity and cancer research. This article delivers stepwise workflows, troubleshooting guidance, and actionable protocol insights grounded in recent breakthroughs linking PFTα to protection against deltamethrin-induced hippocampal dysfunction.

• Dose-Dependent Immune Dynamics in Porcine Deltacoronavirus I

  2026-05-26

  This study reveals how varying doses of porcine deltacoronavirus (PDCoV) distinctly modulate the host immune response in intestinal epithelial cells. By linking viral dose to the scale and nature of STAT1-driven antiviral and inflammatory pathways, the findings offer mechanistic insights for future immunomodulatory strategies against PDCoV.

• EGCG Nanoparticles Enhance FLASH-RT via DNA Damage and Immun

  2026-05-26

  This study demonstrates that functionalized self-assembled EGCG nanoparticles (BENPs) significantly boost the efficacy of ultra-high dose rate radiotherapy (FLASH-RT) by enhancing DNA double-strand breaks and antitumor immune responses. The findings suggest a promising strategy for improving cancer treatment outcomes while maintaining biosafety.

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